The Great Religion is the state religion of the Symphonate, and is also an established religion in the League, though those clerics willingly collaborating with the secular government of the League are considered to be in schism by the College of Priests.

In the distant past, the Great Religion was more of what one might normally consider a religion, teaching about morality, the afterlife, theology, and so forth, with its ceremonies marking lifecycle events and various holidays. It focused on the wormhole Builders, and attempting to discern their will. For many centuries, however, the main concern of the Great Religion is the study and adjudication of their law of technological strictures, the Great Pale, and their laws of civilized warfare, the Lesser Pale. The Great Religion also has had, historically a fair bit to say about other topics, such as trade and lifestyle, but these teachings have largely become inoperative as the Symphonate focused the efforts of the priesthood at maintaining the Pale above all else.

The Great Religion is often seen in highly syncretic local forms, or practiced alongside other religions. As long as the priesthood is free to monitor a society for violations of the Pale and to educate people on the topic, the Symphonate rarely attempts to impose any kind of religious orthodoxy.

The so-called outer priesthood of the Great Religion is composed of a vast technical staff who build, operate and maintain stardrives throughout the Symphonate.

Any sophont can become a cleric of the Great Religion. The hierarchy attempts to recruit diverse species and cultures, and often focuses on attempting to recruit from planets newly added to the Symphonate, to help them assimilate and learn the Pale.